Figure 4

Functionalization of magnetic and gold coated magnetic nanoparticles: the chemisorption of LAA onto Fe₃O₄ (a), the carboxylation of Fe₃O₄@Au using mercaptopropionic acid (b), the activation of the carboxyl groups on the particle, the formation of N-hydroxysuccinimidyl ester in the presence of EDC (c), and the immobilization of huPrPrec onto particles (d). R₁ denotes nanoparticles.