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Table 2 Pharmacokinetic parameters (Mean ± SD, n = 6) of CXB from C2, NGC2 and capsule

From: Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion

Formulation

tmaxa ± SD

(h)

Cmaxb ± SD

(ng/ml)

AUC0→tc ± SD

(ng/ml.h)

AUC0→αd ± SD

(ng/ml.h)

C2

12 ± 1.8

680 ± 100

14435 ± 1741

19711.3 ± 2012

NGC2

12 ± 2.0

610 ± 148

13005 ± 1502

17507.3 ± 1654

Capsule

3 ± 0.8

690 ± 180

4366 ± 1015

4688.5 ± 1293

  1. a time of peak concentration; b peak of maximum concentration; c area under the concentration time profile curve until last observation; d area under curve extrapolated to infinity
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Journal of Nanobiotechnology

ISSN: 1477-3155

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