Figure 7
Systemic treatment with PS-341 attenuates Pa -LPS induced pro-inflammatory response and neutrophil levels. Cftr-/- mice (n = 3, each group) were treated with Pa-LPS and/or PS-341 by intraperitoneal injection. Control, untreated group, was injected with 100 μl saline. The serum cytokine levels were quantified by sandwich ELISAs. We observed that treatment with the PLGA-PEGPS341 decrease Pa-LPS induced A) IL1-β and B) IL-6 levels indicating that PS-341 can control Pa-LPS induced inflammatory response (*p < 0.05) if delivered efficiently to the airway. The data indicates that PS-341 can control Pa-LPS induced inflammatory response.