From: Critical review of the safety assessment of nano-structured silica additives in food
Species | Study length | Effect | LOAEL | NOAEL | Reference |
---|---|---|---|---|---|
Wistar rats | 5–8 weeks | Liver atrophy | 1000 mg/kg body weight per day | 500 mg/kg body weight per day | |
Balb/c mice | 10Â weeks | Fatty liver | 1500Â mg/kg body weight per day | NA | [31] |
Sprague–Dawley rats | 12 weeks | Periportal liver fibrosis | 810 mg/kg body weight per day | NA | [32] |
Fischer rats | 103Â weeks | Reduced liver weight | 1000Â mg/kg body weight per day | 500Â mg/kg body weight per day | [33] |