Recent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapy

Table 4 Examples of stimuli-responsive nanotherapeutics

Stimulus factor	Nanoformulation	Active compound	Tested cancer cell lines	Reference
AMF	Iron oxide/gold nanoparticles	DNA	Human cervical HeLa cells	[218]
GSH	PEGylated, RGD-modified, and DSPEIs-functionalized gold nanorods	shRNA	Human glioblastoma U-87 MG-GFP cells	[219]
GSH	mPEGylated PLA-conjugated micelles	Curcumin	Human cervical HeLa cells	[220]
Light	Bridged silsesquioxane nanoparticles	Plasmid DNA	Human cervical HeLa cells	[221]
Light	Micelles	Cisplatin prodrug and cyanine dye (Cypate)	Cisplatin-resistant lung cancer A549 cells	[222]
Light/pH	Chitosan derivative-coated CNTs encapsulated in nanogel	Doxorubicin	Human cervical HeLa cells	[223]
pH	mPEGylated PLGA-P-Glutamic acid nanoparticles	Doxorubicin	Lung cancer NCI-H460 cells, breast cancer MCF-7 cells	[224]
pH	Multifunctional amphiphilic block copolymer containing cyclic orthoester and galactose groups	Doxorubicin	Liver hepatocellular carcinoma HepG2 cells	[225]
pH	Porous bowl-like PLA-modified MSNs	Doxorubicin	Gastric cancer HGC-27 cells	[226]
pH/GSH	Multi-layered nanocomplexes	Doxorubicin, siRNA	Human hepatocarcinoma QGY-7703 cells	[227]

Multifunctional “smart” nanoparticles carrying drugs targeted preferentially to the cancer cells will lead to development of better treatment for patients with cancer

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