Fig. 5
Cellular uptake of Ag NPs at single cell level as analyzed by LA-ICP-MS. Depicted are overlapping contour plots of 107Ag with cell morphology of Neuro-2a cells after incubation with 2 μg/mL 50 nm (a) and 75 nm (b) Ag NPs. Histogram for the amount of Ag determined in single cells upon incubation with Ag NPs (bin width: 0.02 ng) (c). Histogram of the numbers of Ag NPs per cell (bin width: 15,000 NPs) (d). Histograms (c) and (d) were calculated from three ablated areas on the slide