Table 1 Physical characterization of imipenem/cilastatin loaded polycaprolactone (IMP/PCL), and imipenem/cilastatin loaded polylactide-co-glycolide (IMP/PLGA) nanoparticles
Used polymer | Size (nm) | Zeta potential (mv) | Encapsulation efficiency (EE) % | Drug loading (DL) % | Nanoparticle yield (NY) % | ||
|---|---|---|---|---|---|---|---|
Imipenem | Cilastatin | Imipenem | Cliastatin | ||||
PCL | 132 ± 20 | 17 ± 1.6 | 83 ± 2.2 | 81 ± 1.2 | 17.7 ± 0.6 | 17.3 ± 0.7 | 93 ± 2.7 |
PLGA | 348 ± 65 | 15 ± 0.6 | 76 ±1.2 | 77 ± 3.8 | 17.2 ± 1.3 | 17.6 ± 0.9 | 88 ± 1.9 |