Fig. 1

Schematics showing the structure of the intelligent responsive macrophage cell membrane-camouflaged MSNR drug delivery system for accumulation, drug release and treatment in tumor tissue. A Macrophage cell membrane coating mediated immune evasion, active tumor targeting, and deep tumor penetration. B Weakly acidic tumor microenvironment mediated membrane detachment to promote uptake of nanocarriers by tumor cells. C NIR mediated enhanced synergism of PTT, PDT and chemotherapy