Fig. 7

Quantitative proteomic analysis of extracellular microparticles reveals enrichment of death related proteins in apoHPC-MPs. A Differentially expressed (up-regulated) proteins between apoHPC-MPs and MPs were classified by GO annotation based on the following category: biological process. The bubble chart shows the top 20 categories with the most significant enrichment. The vertical axis shows the function classification. The x-axis indicates Log2 of the ratio of the number of differential proteins in the corresponding function classification to the number of total proteins identified. The colors of the points represent the P values of enrichment significance. The sizes of the dots represent the numbers of differential proteins in the corresponding function classification. B Annotation of differentially expressed (up-regulated) proteins between apoHPC-MPs and MPs based on the KEGG pathway database. The bubble chart shows the top 20 categories with the most significant enrichment. The vertical axis shows the functional pathway. The x-axis indicates Log2 of the ratio of the number of differential proteins in the corresponding pathway to the number of total proteins identified. The colors of the points represent the P values of enrichment significance. The sizes of the dots represent the numbers of differential proteins in the corresponding pathway. C Based on the MS results, heat map of the up-regulated gene encoding death-related proteins in apoHPC-MPs compared to MPs