Table 2 Pharmacokinetic and brain biodistribution parameters of ATS, TMP and DHA (n = 4)
Compounds | Administration | Samples | AUC(0-t) (μg/L·h) | Cmax (μg/L) | Tmax (h) | MRT(0-t) (h) |
|---|---|---|---|---|---|---|
ATS | i.n | Plasma | 4915.556 ± 1413.94 | 879.559 ± 309.656 | 2.396 ± 3.749 | 9.801 ± 1.556 |
Brain | 11.128 ± 3.797 | 1.663 ± 1.070 | 3.500 ± 1.000 | 7.895 ± 0.299 | ||
i.v | Plasma | 5387.243 ± 529.557 | 938.105 ± 444.814 | 0.292 ± 0.308 | 11.039 ± 1.269 | |
Brain | 2.684 ± 0.711 | 0.208 ± 0.023 | 8.250 ± 5.188 | 9.764 ± 0.736 | ||
TMP | i.n | Plasma | 10,144.79 ± 461.39 | 8521.69 ± 1283.845 | 0.083 ± 0.000 | 9.79 ± 0.393 |
Brain | 682.381 ± 95.191 | 1794.855 ± 213.922 | 0.083 ± 0.000 | 3.583 ± 0.555 | ||
i.v | Plasma | 10,431.609 ± 312.259 | 8917.914 ± 1704.089 | 0.104 ± 0.042 | 8.376 ± 0.249 | |
Brain | 372.172 ± 20.836 | 980.815 ± 130.674 | 0.083 ± 0.000 | 3.884 ± 0.404 | ||
DHA | i.n | Brain | 224.205 ± 19.141 | 175.042 ± 54.372 | 0.396 ± 0.283 | 7.683 ± 0.829 |
i.v | Brain | 49.942 ± 14.06 | 16.797 ± 5.249 | 0.125 ± 0.048 | 10.915 ± 2.593 |