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Scheme 1 | Journal of Nanobiotechnology

Scheme 1

From: Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes

Scheme 1

Schematic illustrations of the preparation of Rg3-Lp/DTX and its mechanism on TNBC inhibition. A Preparation process of Rg3-Lp/DTX. B The multiple functions of Rg3 as a tumor targeting material and crosstalk inhibitor between CAFs and tumor cells. Rg3-Lp/DTX can actively target to tumor cells through Glut1-Rg3 interaction. After uptake by tumor cells, Rg3 can prevent tumor cells from secreting TGFβ, a tumor-secreted cytokine that educates the activation of CAFs. With the diminishment of activated CAFs, Rg3-Lp/DTX can penetrate deeper into tumor tissue to exert combined cytotoxic effect of DTX and Rg3 and convert the TEM from “cold” to “hot”. As a result, Rg3-Lp/DTX can achieve excellent anti-TNBC effect

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Journal of Nanobiotechnology

ISSN: 1477-3155

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