Fig. 6

Effects of EPO-PLGA-PEG on hemoglobin and in vivo release in mice. A EPO-PLGA-PEG was not associated with a significant increase in hemoglobin whereas systemic EPO resulted in a significant increase on days 7 and 14 outside of the normal range (n = 5/group; mean ± SEM; ^***p < 0.001 vs. saline, PLGA-PEG, and EPO-PLGA-PEG groups). B EPO-PLGA-PEG was not associated with a significant increase in serum EPO (n = 5/group; mean ± SEM).