Fig. 2

Renal clearance and urinary excretion of s-GOs and l-GOs after i.v. injection in mice. a Renal clearance patterns of s-GOs and l-GOs after i.v injection. b Urinary excretion kinetics of s-GOs and l-GOs. c Raman spectra of urine samples of s-GO and l-GO administrated mice. d Renal clearance rate of s-GOs and l-GOs. Renal clearance rate is the ratio of urinary excretion of GO ([U] × v) to plasma concentration. [U]: urinary GO concentration; v: urine flow rate (0.002 ml/min). e LA-ICP-MS images of the distribution of Yb labelled GOs (s-GOs/Yb and l-GOs/Yb) in the kidney at 4 and 24 h post-injection. f Raman spectral images of s-GOs and l-GOs in renal cortex at 48 h after i.v. injection. From left to right: Bright field (BF) image; Raman image (RI) of autofluorescence (blue color) or GOs (yellow color, obtained from Raman spectrometry); merge image of tissue and GOs