Fig. 4

In vivo therapeutic efficiency of UCNPs@Ce6/3HBQ@CM. a UCL images of tumor-bearing mice after intravenous injection with the same dose of UCNPs@Ce6/3HBQ or UCNPs@Ce6/3HBQ@CM. b Quantitative analysis of UCL intensity in the brain at different times after injection of the two nanocomposites. c Ex vivo UCL images of the brain and major organs of tumor-bearing mice at 4 h after injection of the two nanocomposites. 1-Brain, 2-Liver, 3-Heart, 4-Kidney, 5-Spleen, 6-Lung. d Bioluminescence images of U87MG-Luc glioma-bearing mice treated with different conditions. e Quantitative bioluminescence intensity in the brain of the mice in d. f Body weight of U87MG-Luc glioma-bearing mice after receiving different treatments. g Kaplan–Meier survival curve of U87MG-Luc glioma-bearing mice with different treatments. Data are presented as mean ± SD (n ≥ 3). *P < 0.05, **P < 0.01, and ***P < 0.001. (h) Whole brain H&E staining of tumor-bearing mice treated with different conditions, and the dotted line showed the tumor area. H&E staining and TUNEL staining images of the tumor area