Fig. 9

CHSY3^−/− abolished the effect of IDD therapy with low-dose celecoxib. a HE staining. b SOFG staining of the intervertebral disc of WT and CHSY3^−/− mice treated with low-dose celecoxib and high-dose celecoxib. c WT and CHSY3^−/− mice. d Degeneration score of HE. e IHC result of CHSY3 of the intervertebral disc of WT and CHSY3^−/− mice. f–i PCR results of ACAN (f), COL2A1 (g), MMP3 (h), MMP13 (i) of the intervertebral disc of WT and CHSY3^−/− mice. j PGE2 concentration of the intervertebral disc detected by ELISA. *P < 0.05 compared with the sham group, ^#P < 0.05 compared with the low LSI group, and ^†P < 0.05 compared with the high LSI group