Fig. 2

Biocompatibility of CLDENs. A CLDENs accumulated intracellularly over time after uptake. White triangles were used to mark RAW264.7 cells’ morphological changes after ingestion of CLDENs. Scale bar = 20 μm. B Cytotoxicity assay of CLDENs against multiple cell lines (n = 3). C Hemolysis test under different concentrations of CLDENs by using blood of sheep (n = 3). D Changes in the particle size distribution of CLDENs after incubation in PBS (a), stomach simulating fluid (b) and small intestine simulating fluid (c) at 37 °C