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Table 2 Effect of CLDENs on the organ index of cyclophosphamide-induced immunosuppression mice

From: Novel plant-derived exosome-like nanovesicles from Catharanthus roseus: preparation, characterization, and immunostimulatory effect via TNF-α/NF-κB/PU.1 axis

Groups

Organ index (mg/g)

Spleen

Thymus

Heart

Liver

Kidney

Blank

2.38 ± 0.25

1.41 ± 0.82

5.45 ± 0.63

46.38 ± 8.38

16.13 ± 2.64

Model

1.42 ± 0.27***

0.67 ± 0.33*

5.46 ± 0.55

50.87 ± 2.81

16.13 ± 1.75

CLDENs-L

1.97 ± 0.22*, ##

0.46 ± 0.32**

5.27 ± 0.52

52.63 ± 4.00*

15.56 ± 0.95

CLDENs-M

2.50 ± 0.50###

0.82 ± 0.40

4.94 ± 0.79

51.62 ± 5.36

15.70 ± 1.71

CLDENs-H

3.39 ± 0.54***, ###

0.70 ± 0.48*

5.21 ± 0.78

50.06 ± 3.24

15.40 ± 1.41

  1. Data were mean ± SD, n = 10; *P < 0.05, **P < 0.01 and ***P < 0.001 vs. Blank; ##P < 0.01 and ###P < 0.001 vs. Model