Fig. 5
From: Microenvironment of pancreatic inflammation: calling for nanotechnology for diagnosis and treatment
Copyright 2022, Frontiers Media S.A
A SPIO@SiO2@MnO2Â shows weak T1 and T2 contrast intensity in normal physiological conditions, as the T2 signal of SPIO is quenched by the MnO2 layer. In the acidic environment of a tumor or inflamed tissue, the MnO2 layer will decompose into magnetically active Mn2+ (T1-weighted), and the T1 and T2 signals are sequentially recovered. Reproduced with permission from reference [104]. Copyright 2022, Springer Nature B The cumulative release of COSs from COS@SiO2 at pH 7.4 and pH 8.0. Reproduced with permission from reference [105]. Copyright 2020, Frontiers Media S.A. C Schematic illustration of biodegradation, ROS scavenging effects, and enhanced theranostic functions by Fe/Ce-MSN-PEG NPs. Reproduced with permission from reference [108].