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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Stem cell-derived small extracellular vesicles embedded into methacrylated hyaluronic acid wound dressings accelerate wound repair in a pressure model of diabetic ulcer

Fig. 6

In vivo experiments on pressure ulcer model. (A) Schedule of the experiment. (B) Representative photos of the ulcers at different post-lesion times in standard of care (SoC) and MSC-sEVs treated (Exo) db/db mice. (C) Ulcer areas expressed as a percentage of the skin lesion area at day 0. (D) Cytokines expression profile. (E) Extracellular matrix proteins and remodeling enzymes expression profile. (F) Wound repair in ulcers medicated with 120 µg or 20 µg of MSC-sEVs and MeHA patches previously loaded with 120 µg MSC-sEVs. (G) Representative micrographs of hematoxylin-eosin staining in skin biopsy. (H) Morphometric evaluation of epidermal thickness. (I) Representative micrographs of laminin-IR in skin biopsy. (J) Morphometric evaluation of laminin-positive percentage area. (K) Representative micrographs of PGP 9.5-IR fibers in skin biopsy. (L) Morphometric evaluation of PGP 9.5-positive percentage area. *p < 0.05, **p < 0.01, ****p < 0.0001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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