Skip to main content
Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway

Fig. 5

Human adipose-derived mesenchymal stem cell extracellular vesicles (hASC-EVs) regulate cellular protection from oxidative stress damage via PI3K/Akt/NRF2 signaling. a The top 20 miRNAs in hASC-EVs were examined using human miRNA sequencing. miRNA profiling and gene target analysis using the KEGG and GO databases were performed on the target genes of miRNAs enriched in hASC-EVs. b Significantly enriched KEGG pathways and c GO terms of biological processes (BPs), cellular components (CCs), and molecular functions (MFs). d Western blot results showing PI3K, p-PI3K, Akt, p-Akt, NRF2, KEAP-1, P62, and HO-1 protein expression in dental follicle cells (DFCs). e Representative images showing NRF2 expression in DFCs. Scale bar = 20 μm. f Histogram illustrating the quantitative analysis of p-PI3K, p-Akt, NRF2, KEAP1, P62, and HO-1 protein expression in different groups. g Quantification of NRF2 immunofluorescence intensity. *P < 0.05, **P < 0.01, and ***P < 0.001, compared to the control

Back to article page

Journal of Nanobiotechnology

ISSN: 1477-3155

Contact us