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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway

Fig. 6

Human adipose-derived mesenchymal stem cell extracellular vesicles activate NRF2/HO-1 signaling via the PI3K/Akt pathway. a Western blot results showing PI3K, p-PI3K, Akt, p-Akt, NRF2, KEAP1, P62, and HO-1 protein expression in dental follicle cells pretreated with the PI3K/Akt inhibitor LY294002. b Histogram illustrating the quantitative analysis of p-PI3K, p-Akt, Keap-1, NRF2, and HO-1 protein expression after pretreatment with the PI3K/Akt inhibitor LY294002. c Changes in the NRF2 signaling pathway after Nrf2 knockdown. d Histogram illustrating the quantitative analysis of NRF2, KEAP1, P62, and HO-1 protein expression in different groups. e Changes in the expression of odontogenesis- and osteogenesis-associated proteins after Nrf2 knockdown. f Histograms illustrating the quantitative analysis of COL1, DSPP, periostin, DMP-1, and RUNX2 expression. g ALP and h ARS staining in different treatment groups after Nrf2 knockdown. Scale bar = 500 μm. Histograms showing quantification of mineralization (i) and ALP activity (j) in different treatment groups after Nrf2 knockdown. *P < 0.05, **P < 0.01, and ***P < 0.001, compared to the control

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Journal of Nanobiotechnology

ISSN: 1477-3155

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