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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy

Fig. 2

Characterization and properties of PFCR. A Scanning electron microscopy (SEM) images of PFCR hydrogel revealed its structure and morphology. B The fluidity of the PFCR hydrogel at both 4 and 37 °C was investigated, indicating its temperature-dependent behavior. C Rheology studies showed the temperature-dependent viscoelastic properties of PFCR aqueous dispersion. D Steady-shear rheology demonstrated the shear-thinning behavior of PFCR. E Frequency-dependent rheology analysis of PFCR hydrogel at 37 °C. F In vitro cumulative release experiments of ropivacaine from PFCR (n = 3). G In vitro cumulative release experiments of cisplatin from PFCR (n = 3). H The occurrence of convulsions in mice administered with PFCR or a cisplatin-loaded PF127 hydrogel plus free ropivacaine (PFC + Rop) was statistically analyzed (n = 7). Data are presented as the mean ± SD. PFC + Rop: cisplatin-loaded PF127 hydrogel plus free ropivacaine; PFCR: cisplatin and ropivacaine-coloaded PF127 hydrogel

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Journal of Nanobiotechnology

ISSN: 1477-3155

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