Fig. 8

N-S1 PNp immunization altered transcriptional characteristics. A Venn diagrams of differentially expressed genes (DEGs) compared to PBS, numbers indicate unique and common DEGs in four groups. B MA maps displaying DEGs of PBS versus N-S1 PNp, Soluble N, Soluble S1, and Soluble S1 + N. C Volcano maps showing differential gene expression of N-S1 PNp versus PBS, Soluble N, Soluble S1, and Soluble S1 + N. The splash represents various genes, with significant (p < 0.05) up-regulated and down-regulated DEGs represented by red or green dots, respectively, while gray dots represent genes with no significant change