Fig. 10

Strategies and applications of exosome-enhanced immunotherapy. A Engineered exosomes for cancer immunotherapy. Reproduced with permission. [178] Copyright 2020, Wiley. B HEK293-derived exosomes loaded with R848 (immunoadjuvant) and Ce6 (sonosensitizer) promoted DC2.4 maturation. (I) ExoR848 + Ce6 intervention DC2.4 schematic diagram. (ii) Western blot analysis of Hsp70 in DC2.4 from different treatment groups. (iii) The production of ROS in the different treatment group DC2.4 (scale = 100 microns) and statistical analysis. (iv) Flow cytometry and statistical analysis of CD80 and CD86 expression in DC2.4 of different treatment groups. Reproduced with permission. [140] Copyright 2022, Informa UK Limited