Fig. 9

The application of exosomes delivering biological macromolecules in cancer therapy. A Schematic diagram of the synthesis and cell-targeted delivery of Exosomes for protein loading via optically reversible protein–protein interactions (EXPLORs). Reproduced with permission. [164] Copyright 2016, Springer Nature. B Synthesis and characterization of exosomes loaded with nucleic acid nanoparticles (NANPs). Reproduced with permission. [165] Copyright 2020, Elsevier Inc. C Schematic representation of cisplatin elicited exosomes loaded with miR-29a-3p inhibiting metastasis of Lewis lung carcinoma cells in mouse lungs (i) and HE staining image of the lung (ii), scale bar = 2 mm. (iii) By Masson staining showed two groups of mice lung tumors and the tumor area of total collagen protein expression level (scale = 100 microns). (iv) Collagen I expression levels (scale bar = 100 μm) at the tumor edge and tumor core in the lung of the two groups of mice by IHC staining (scale = 100 μm). Reproduced with permission. [172] Copyright 2022, Elsevier B.V