Fig. 7

Macrophage phenotypic switching in bone defect model. A Immunofluorescent images of sections in different groups after implantation for 4 weeks: red (M1 marker: iNOS), green (M2 marker: CD206). B Immunochemistry images of sections in different groups after implantation for 4 weeks. C Immunofluorescent images of sections in different groups after implantation for 12 weeks. D Immunochemistry images of sections in different groups after implantation for 12 weeks. E The M2/M1 ratio of different groups after 4 weeks of implantation. F, G The proportion of IL-6 and IL-10 positive cells after 4 weeks of implantation. H The M2/M1 ratio of different groups after 12 weeks of implantation. I, J The proportion of IL-6 and IL-10 positive cells after 12 weeks of implantation. n = 6. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001