Fig. 4

A novel multiresponsive adjuvant nanoparticle (R837@MSN-mannose- AuNPs-Glu/Lys) is fabricated to perform tumor-specific photothermal therapy while also working as a tumor-associated immune cell modulator for primary tumor eradication and prevent metastasis. A This schematic depicts the release of R837 and AuNPs-Glu/Lys for tumor-specific photothermal therapy in an acidic environment (pH 6.7), and the TGase-mediated aggregation of detached AuNPs-Glu/Lys. B Tumor-bearing mice treated with PBS, MmAGL, and RMmAGL combined with and without NIR irradiation are shown in vivo photothermal images. C A digital picture of the final tumor tissue and a graph showing the growth curve of the tumor after treatment with different formulations. D After 21 days of treatment with different formulations, tumor tissue mass was collected. E Following treatment with different formulations, BALB/c mice's lungs were photographed. F Different groups of lung samples were examined for metastatic nodules. G Histological images taken from different groups of lung samples undergoing H&E staining. H Different groups' average lung weights. I Curves of body weight in tumor-bearing mice treated with different formulations. J Tumor-bearing mice's survival percentages after treatments with different formulations. Adapted with permission from ref [221]. Copyright (2023) Advanced materials. AuNPs, gold nanoparticles; MSN, mesoporous silica nanoparticles; RMmAGL, Multiresponsive adjuvant nanoparticles; Glu, glutamine; Lys, lysine; Cys, cysteine; NIR, near-infrared. There are five groups: PBS, MmAGL, RMmAGL, MmAGL with NIR irradiation, and RMmAGL with NIR irradiation