Fig. 5

S-AgNP elicited a synergistic antitumor effect and induced CD8⁺ T cell activation in an immunocompetent mouse model. A The production of S-AgNPs was improved by redesigned evaporation–condensation protection systems. B An image of the tumor burden after S-AgNPs treatment in various B16-F10 tumor burden models. C Tumor volume was measured at the endpoint of the study in B16-F10 xenografts. D Tumor mass was measured at the endpoint of the study in B16-F10 xenografts. E A representative image of CD8⁺, CD8⁺GZMB⁺, and CD8⁺IFN-γ⁺ cells in CD45⁺ TILs collected from wild-type C57BL/6 B16-F10 xenografts treated with S-AgNPs. F and G S-AgNPs-treated C57BL/6 mice with B16-F10 xenografts are shown in images with IF staining for CD8 or GZMB. Adapted with permission from ref [251]. Copyright (2022) Journal of Colloid and Interface Science. S-AgNPs, AgNPs coated with sucrose; IFN-γ, Interferon-gamma; TEM, transmission electron microscopes; TILs, tumor infiltrating lymphocytes; GZMB, Granzyme B