Fig. 3

In vitro macrophage uptake. Small animal imaging was used to detect drug distribution in vivo (A). PKH-26 dye intensity was measured in stomach and intestine using the Living Image software (B). Colocalisation of mouse intestinal macrophages and fluorescently labelled GDNPs. Scale bar: 100 μm (C). Confocal images showing uptake of DIO-labeled GDNPs by RAW264.7 in vitro cultures. Scale bar: 200 μm (D). Data are expressed as mean ± SD. n = 3. **p < 0.01 vs. PBS group (One-way ANOVA and Dunnett’s post-hoc test)