Fig. 8

GDNPs regulate intestinal stem cell proliferation and differentiation. Labelled GDNPs colocalise with intestinal stem cells in the mouse intestine. Scale bar: 100 µm. A Transcription levels of proliferative and differentiation factors (BMI-1, CDX1 and MUC2) in intestinal stem cells in mice treated with and without GDNPs (B). Expression levels of the intestinal stem cell marker Lgr5 and of the proliferative and differentiation protein Wnt 3A, β-catenin, TGF-β1, and Ki67 (C). Densitometric analysis was performed with ImageJ Software. Data are presented as mean ± SD. n = 3. ^#p < 0.05 and ^##p < 0.01 vs. Control; *p < 0.05 and **p < 0.01 vs. mice treated with DSS only (One-way ANOVA and Dunnett’s post-hoc test)