Fig. 6

Biodistribution and histological examination of the HFD-fed obese rats after the intraperitoneal administration of combined α-tocopherol and CLA in free or nanoparticulate form: (A) real-time bioimaging of the CLA-loaded tocol NLCs in the rats within 24 h; (B) the biodistribution of CLA-loaded tocol NLCs in different organs/tissues at 24 h post-administration; (C) H&E staining of liver; (D) FAS expression of the liver determined by IHC; (E) F4/80 expression of the liver determined by IHC; (F) H&E staining of groin; and (G) H&E staining of epididymis. Scale bar = 100 μm