Fig. 7

The safety assessment of combined α-tocopherol and CLA in free or nanoparticulate form by intraperitoneal administration on the healthy rats: (A) the body weight change during 3 weeks of repeated (6 times) administration; (B) total cholesterol in plasma after 3 weeks of repeated (6 times) administration; (C) AST and ALT concentration in plasma after 3 weeks of repeated (6 times) administration; (D) BUN and CRE concentration in plasma after 3 weeks of repeated (6 times) administration; (E) H&E staining of liver; (F) H&E staining of groin; and (G) H&E staining of epididymis. All data are presented as the mean of six experiments ± S.E.M. * p < 0.05 as compared to the control group. Scale bar = 100 μm