Schematic representation of the action of GHE nanocatalyst for NIR-triggered enhanced locoregional thermoenzymatic-photothermal therapy. Rapid endocytosis of GHE by breast cancer cells is enhanced by active receptor-ligand targeting. Subsequently, a synergistic and precise AA deprivation/photothermal-therapy based on GHE nanocatalyst induces multipath cell death via NIR-triggered procedure