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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Computational design and engineering of self-assembling multivalent microproteins with therapeutic potential against SARS-CoV-2

Fig. 5

Experimental verifications of the trivalent constructs of miniACE2. a SEC profiles of the purified proteins of the constructs. b Native-PAGE analysis of the protein trimer fractions isolated from SEC. c BLI measurements of the binding kinetics of the monovalent miniACE2 and the trivalent construct, MP-5ff, to the immobilized RBD of SARS-CoV-2 (Wuhan-Hu-1). Red traces represent the raw data and the kinetic fits are shown in gray. d Neutralizing activity of miniACE2 and MP-5ff against SARS-CoV-2 pseudovirus (Wuhan-Hu-1)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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