Fig. 5
Hsa_circ_0004085 relieved 5-Fu/Oxa-induced ER stress, thereby conferring drug resistance to CRC cells. A Western blot analysis of the influence of hsa_circ_0004085 on key markers of the cell death pathway induced by Oxa/5-Fu. B ER tracking analysis examined the influence of hsa_circ_0004085 on ER-tracker MFI in LOVO cells treated with Oxa/5-Fu. C IF was used to examine the influence of hsa_circ_0004085 on the PDI MFI in LOVO cells treated with Oxa/5-Fu. (*P < 0.05, **P < 0.01, ***P < 0.001, NS: not signifcant)