Fig. 6

The TME were remodeled after VNP-shCCDC25 administrations. A, B The percentage of tumor-infiltrating NEs was analyzed via FACS, 5 days after treatments. C, D The percentage of TNF-α positive cells in tumor-infiltrating NEs was analyzed via FACS. E Similarly, the percentage of tumor-infiltrating Mφs was analyzed via FACS, and the statistic diagrams were shown in (F). G The FACS histogram plot of TNF-α positive cells in tumor-infiltrating Mφs. H The statistic diagrams of TNF-α⁺ Mφs in tumor-infiltrating Mφs. I-K The mRNA expression level of TNF-α、IL-1β、TGF-β in the metastatic foci of B16F10 lung metastasis model was analyzed via qPCR. Data are shown as the mean ± SD. **** p < 0.0001, *** p < 0.001, ** p < 0.01, * p < 0.05, ns: no significance