Fig. 6

The administration of hADSC-Exos effectively ameliorates ASD-like behavior in BTBR mice. a Timeline of tests for extensive behaviors. b Self-grooming test. 10-min’ self-grooming test is conducted. c Marble burying test. 10-min’marble burying test is conducted. d, e Novel object preference (NOP) test. Each group was allowed to explore objects in order to test its novelty preference using the novel object preference test. f, g Three-chambered test. After 3-day training period in which mice were exposed to the unfamiliar mice #1, unfamiliar mice #2 was placed in sociability test session (f) and social novelty preference (g). Quantified the residence time of the experimental mice in the unfamiliar mice area. Two-way ANOVA with Tukey’s multiple comparison test. n = 6–12 mice per group for behavior, and Bars represent mean and error bars S.E.M. *p < 0.05, **p < 0.01, ***p < 0.001