Fig. 7

LncRNA IFNG-AS1 expression was significantly associated with ASD in hADSC-Exo. a Venn diagram demonstrating the intersections of genes from the ASD lncRNA set, brain development-related lncRNA set, hADSC-Exo lncRNA set and Homologous lncRNA data. b Quantification of the expression levels of nine candidate lncRNAs within hADSC-Exo was performed using qRT-PCR. c qRT-PCR technique was employed to detect the expression levels of 9 candidate lncRNAs in BTBR mice subsequent to treatment with hADSC-Exo. d Predicting on lncRNA Ifngas1-ASD associations in RNADisease database. e Combined immunofluorescence experiments of FISH with Tuj1 antibody (green) and Ifngas1 (red) show the distribution of Ifngas1 in neurons of cortical slices in WT mice. Enlarged images are shown at the bottom of the group. Scale bars = 100 μm (upper), 20 μm (lower). Two-way ANOVA as appropriate. By Tukeys multiple comparison test. Three biological replicates were used in the experiments. *p < 0.05, **p < 0.01, ***p < 0.001