Fig. 6

Measurement of E. coli O157:H7 in mouse serum. a Schematic representation of the methodology employed to establish an E. coli O157:H7-infected mouse model and subsequent blood collection; b Raman intensity profiles of six mice infected with E. coli O157:H7 and six healthy mice (represented by the broken line) are shown, along with the average trace (indicated by the red and black lines). The error bars represent standard deviations; c Raman intensity of E. coli O157:H7 expressed in serum of infected mice and healthy mice at the indicated times (paired two-tailed Student’s test, *P < 0.05, **P < 0.01, ***P < 0.001); d ROC curve analysis was performed to compare healthy mice (n = 6) with E. coli O157:H7-infected mice (n = 6)