Fig. 3
From: NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy
(A) Thermal image of PC-3 tumor loaded mice injected with different samples under 808 nm laser irradiation (1.5 W/cm2). (B) The protein expressions of VEGFA, E-cadherin and HSP70 in 4T1 cells analyzed by western blotting (I: E-cadherin, II: HSP70, III: VEGFA, C: GAPDH). (C) Fluorescence stain images of CRT expression in PC-3 cells with different treatments. (D) mRNA expressions of VEGFA, E-cadherin and HSP70 in PC-3 cells were tested by quantitative real-time PCR (a: saline, b: LMDFP, c: LMDFP + Laser). (E) In vivo NIR-IIb fluorescence imaging at different time points of the nude mice bearing PC-3 tumor after intravenous (i.v.) injection of LMDFP. (F) ICP-OES of the Nd element concentration in the major organs and tumors at different time points