Fig. 5
From: NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy
The antitumor metastasis study in vivo on 4T1 tumor loaded Balb/c mouse model. (A) Tumor volume growth curves of five treatment groups during the monitoring period. (B) Corresponding 4T1 tumor weight in the different treatment groups after 19 days (**P < 0.01, ***P < 0.001). (C) Photograph of 4T1 tumors obtained from the Balb/C mice after different treatments for 19 days. (D) Representative lung photographs collected from mice after various treatments. White nodules were metastatic tumors in the lungs. (E) H&E staining of lung metastatic lesions after different treatments. (F) VEGFA, CD31 and HSP70 expression of 4T1 tumor tissues after the various treatments