Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying miR-146a-5p

Table 1 The expression and fold changes (FC) of miRNAs profiles between RmEVs and CmEVs

miRNAs	CmEVs ^a	RmEVs ^b	Log₂FC (RmEVs/CmEVs)	p-value	t-value
miR-6516	43.36 ± 8.20	281.55 ± 55.18	2.708	0.006	-7.40
miR-1285	14356.88 ± 2131.81	39985.57 ± 10624.31	1.942	0.006	-4.09
miR-223	7220.70 ± 1906.24	21259.72 ± 5239.20	1.364	0.002	-4.36
miR-9841-3p	2.11 ± 1.19	55.28 ± 9.64	4.821	0.0002	-9.39
miR-18a	10.98 ± 3.73	291.0535 ± 65.46	4.738	0.002	-6.31
miR-146a-5p	31.42 ± 9.51	124.30 ± 29.91	1.959	0.004	-5.12
miR-142-5p	145.40 ± 24.92	316.79 ± 20.03	1.099	< 0.001	-9.28

^a CmEVs, milk-derived extracellular vesicles from Control; ^b RmEVs, milk-derived extracellular vesicles from maternal dietary RS group. Results were presented as mean ± SD

ISSN: 1477-3155