Fig. 4
From: Spike structure of gold nanobranches induces hepatotoxicity in mouse hepatocyte organoid models
The effects of GNSs/GNBs on the cytotoxicity and morphology of HepG2 cells and Hep-orgs. (a) Cytotoxicity of GNSs and GNBs on HepG2 cells. (b) The results of GNSs and GNBs on ATP production in Hep-orgs. (c) Bright-field optical images of HepG2 cells and Hep-orgs after treatment with GNSs and GNBs. Red arrows point to the outer wall of the Hep-orgs, and black arrow points to the enlarged intercellular space on the outer wall of the Hep-orgs. All data are presented as mean ± SD (the black dots represent the number of samples). *P < 0.05, **P < 0.01, ***P < 0.001