Fig. 5
(A) Illustrated dissolution process of AA/γCD cocrystals. (B) Five typical dissolution profiles of API. (1) Dissolution of insoluble drug with stable crystalline form; (2) Insoluble drug in metastable forms (i.e., amorphous phase) shows quick dissolution and achieves the peak concentration which quickly drops (within minutes to an hour) and transforms to an insoluble crystalline form. (3) Cocrystals can dissolve fast and the supersaturated concentration can be maintained for hours (metastable zone) because of the assistance of water-soluble coformers. (4) Insoluble drugs dispersed by pharmaceutic surfactants can fast disintegrate, and the released API can be stabilized by the surfactant, thus effectively extending the life of the API in solution. (5) Highly soluble drugs can quickly dissolve and maintained a constant concentration in the media