Fig. 7

miR-26a-5p@A-MSN-MG1 delivery system provides sustained relief from inflammatory pain and Chemotherapy-induced peripheral neuropathic (CIPN) pain. A Experimental schematic plot for the establishment of the mouse model of inflammatory pain and chemotherapy-induced peripheral neuropathy. B 50% paw withdraw threshold (PWT) of left hind paw of different treatment inflammatory pain mice groups. At the day of 5, 7 and 14, the paw withdrawal thresholds (WTs) of CFA + miR@A-MSN-MG1 group was significantly higher than those of CFA + miR group. (*p < 0.05, **p < 0.01, ***p < 0.001 compared with SNI + miR group by Two-way ANOVA followed by Tukey post hoc test, n = 8 in each group). C–E 50% paw withdraw threshold (PWT) of left hind paw of different treatment groups of inflammatory pain mice at day 5, 7 and 14. F–I Thermal latency(s) of left hind paw of mice in different treatment inflammatory pain mice groups. J–M 50% paw withdraw threshold (PWT) of left hind paw of different treatment CIPN mice groups. Data are represented as mean ± sem