A novel microglia-targeting strategy based on nanoparticle-mediated delivery of miR-26a-5p for long-lasting analgesia in chronic pain

Table 1 Analgesic efficacy of different delivery systems

Delivery system	Loaded molecules	Pain model	Analgesia duration	Refs.
hPMSCs-exosomes	miR-26a-5p	Neuropathic pain	28 days	[13]
MSN	Δ9-THC and ARA290	Neuropathic pain	28 days	[32]
miR@A-MSN-MG1	miR-26a-5p	Neuropathic pain	42 days	This work
Microcapsule	QX-314	Inflammatory pain	12 days	[41]
Huc-MSCs-exosomes	miR-146a-5p	Inflammatory pain	7 days	[40]
None	miR-26a-5p	Inflammatory pain	5 days	[14]
miR@A-MSN-MG1	miR-26a-5p	Inflammatory pain	at least 14 days	This work

ISSN: 1477-3155