Fig. 5

Treatment with MSC-Exo down-regulates genes related to fibrosis in tissue obtained at day 7. A Heatmap of the expression of 84 genes in the ChGel^MSC−Exo and ChGel^PBS group (n = 3 per group, black represents the mean magnitude of gene expression, the brightest red and brightest green indicates the maximum and minimum magnitude respectively). B Volcano plot of the differentially regulated genes between the ChGel^MSC−Exo and ChGel^PBS group. C–F Heatmap of differentially regulated genes involved in the pro-fibrosis, anti-fibrosis, inflammation and cell proliferation. Please refer to Additional file 1: Table S2 for the full gene names. Pigs, n = 6. All data are shown as the means ± SEM. Statistical significance was analyzed by independent samples t test between two groups, respectively. *P < 0.05, **P < 0.01