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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Macrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling

Fig. 4

Expression of miRNA in cBMDM-sEVs and nBMDM-sEVs. (A) Heatmap analysis of miRNA in cBMDM-sEVs and nBMDM-sEVs (n = 3). (B) Volcano plot of differentially expressed miRNA between cBMDM-sEVs and nBMDM-sEVs. (C) KEGG pathway analyses of differentially expressed miRNA between cBMDM-sEVs and nBMDM-sEVs. (D) GO analyses of differentially expressed miRNA between cBMDM-sEVs and nBMDM-sEVs. (E) mRNA expression of miR-146a-5p, miR-100-5p, miR-27a-3p, and let-7a-5p in cBMDM-sEVs and nBMDM-sEVs by qRT-PCR. (F) mRNA expression of miR-146a-5p and miR-100-5p in RA-FLS co-cultured with PBS, cBMDM-sEVs or nBMDM-sEVs, respectively. Data are presented as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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