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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: An exosomal strategy for targeting cancer-associated fibroblasts mediated tumors desmoplastic microenvironments

Fig. 1

The significance of CAFs in desmoplastic tumors. CAFs secrete abundant ECM proteins and exert physical force to remodel ECM and establish pathological barrier that hinders drugs delivery and immune cells infiltration and promotes cancer cells invasion. CAFs also secret abundant cytokines and ECM proteins to induce immunosuppress and CSCs. Cancer cells affected by CAFs can secrete abundant cytokines to promote CAFs accumulation that form barrier and compress blood vessels. CSF1, colony-stimulating factor 1; FGF5, fibroblast growth factor 5; EMT, epithelial mesenchymal transition

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Journal of Nanobiotechnology

ISSN: 1477-3155

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