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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment

Fig. 5

Mechanism of UTMD in combination with HYD-NDs inducing pyroptosis. (A) TEM photographs of 4T1 cells with different treatments. The red boxes in the upper image can be seen in greater detail in the bottom figures (magnification 2X). Scale bar: 1.2 μm, 0.6 μm. (B) GSDME-N and Cleaved-CASP3 relative expression levels on tumor cells treated differently. (C) Quantification of GSDME-N and Cleaved-CASP3 was performed from B. (D) Fluorescence photographs showing the production of ROS in 4T1 cells following various treatments. Scale bar: 100 μm. (E, F) The expression level (E) and quantitative analysis (F) of GSDME-N and Cleaved-CASP3 in 4T1 cells following different therapies. (G) Release of LDH in culture supernatants. All data are provided as means ± SD (n = 3)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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